A REVIEW OF MASTALGIA IN PATIENTS WITH FIBROCYSTIC BREAST CHANGES COMPAIRINGEFFECTIVENESS OF CENTCHROMAN

Background:Mastalgia and fibrocystic disease of breast (fibroadenosis fibroadenomaare common among the women in reproductive age group.Mostof drugs used for these conditions are expensive have side effects.Centchroman is a novel ono-steroidal antiestrogen,becouse its selective antiestrogenic action cantchroman treatment mastagia fibroadenoma.Centchroman therapy FA showed statistically significant regression volume.and pain. AimsandObjectives:-The purpose this study to effectiveness centchroman on mastalgias fibroadenomasStudy design:Randomized control trial Material: 60 Patients Study follow-up period 1 Year Materials mathods:Patients attending general surgery op with complaints lump less than35 yrs will be taken detailed clinical history, examination, ultrasonagram (USG) both fine needle aspiration (FNAC)/ core biopsy who all diagnosed as fibroadenoma (FA) willing simple observation reassurance at least 6 months included after getting informed consent randomization group group. get Centchroman 30mg orally alternative days patients only assurance. reviewed 1week check tolerance later 4, 12, 24 weeks. USG done 0 days, 12 weeks groups assess Results:The statistical difference reduction their sizes treated even 4th week. Further between became highly 12th 24thweek.The did not show any mastalgia 8th But 24th week greater Conclusions:Centchroman volume.Centchroman inmastalgias pain,Long term results beyond needs further study.It useful patient instead enucleation .Patients more than 35 old young (<35 yrs) suspicious histology, recurrence, family h/o carcinoma breast, anxiousness no response conservative management ideal candidate active excisional ( FA).